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This is a rare cancer that most often begins as a lesion, bump or ulcer on the head of the penis (glans), or the loose fold of skin (prepuce) at the base of the glans. Occasionally, cancer develops in the groove beneath the glans (coronal sulcus) or the shaft itself. Because of its rarity, many doctors often don’t consider penile cancer as a possibility when developing a diagnosis. Early diagnosis is very important, as discovery at its beginning stages presents the best opportunity for a favorable outcome.